Nanoprodrugs of NSAIDs Inhibit the Growth of U87-MG Glioma Cells
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چکیده
منابع مشابه
Nanoprodrugs of NSAIDs: Preparation and Characterization of Flufenamic Acid Nanoprodrugs
We demonstrated that hydrophobic derivatives of the nonsteroidal anti-inflammatory drug (NSAID)flufenamic acid (FA), can be formed into stable nanometer-sized prodrugs (nanoprodrugs) that inhibit the growth of glioma cells, suggesting their potential application as anticancer agent. We synthesized highly hydrophobic monomeric and dimeric prodrugs of FA via esterification and prepared nanoprodru...
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15 صفحه اولMetabolic Impact of Anti-Angiogenic Agents on U87 Glioma Cells
BACKGROUND Glioma cells not only secrete high levels of vascular endothelial growth factor (VEGF) but also express VEGF receptors (VEGFR), supporting the existence of an autocrine loop. The direct impact on glioma cells metabolism of drugs targeting the VEGF pathway, such as Bevacizumab (Bev) or VEGFR Tyrosine Kinase Inhibitor (TKI), is poorly known. MATERIAL AND METHODS U87 cells were treate...
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ژورنال
عنوان ژورنال: Journal of Nanomaterials
سال: 2010
ISSN: 1687-4110,1687-4129
DOI: 10.1155/2010/583970